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DNA Vaccines
Research on DNA vaccines detailed by scientists at Rockefeller University
April 29th, 2008
According to recent research published in the Jaids - Journal of Acquired Immune Deficiency Syndromes, "An effective vaccine against HIV-1 is generally considered the best hope for controlling the raging AIDS pandemic. As a part of our AIDS vaccine development effort, we constructed a dual-promoter plasmid capable of high-level expression of 2 independent transgenes." "HIV-1 gag, pol, env, nef, and tat from a primary subtype C/B' CCR5-tropic HIV-1 were ''codon'' optimized, modified to eliminate known functional activity, and assembled using an overlapping polymerase chain reaction into 2 plasmids: ADVAX-I (containing env and gag) and ADVAX-II (containing pol and...
Source: TB & Outbreaks Week (2008-04-29)
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