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Drug Resistance
Study results from University of Frankfurt provide new insights into drug resistance
April 29th, 2008
According to recent research from Frankfurt, Germany, "Efflux pumps of the small multidrug resistance family bind cationic, lipophilic antibiotics and transport them across the membrane in exchange for protons. The transport cycle must involve various conformational states of the protein needed for substrate binding, translocation, and release." "A fluorescent substrate will therefore experience a significant change of environment while being transported, which influences its fluorescence properties. Thus the substrate itself can report intermediate states that form during the transport cycle. We show the existence of such a substrate-transporter complex for the EmrE...
Source: TB & Outbreaks Week (2008-04-29)
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