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Infectious Disease
New infectious disease research reported from M. Mezger and co-authors
April 29th, 2008
"Invasive fungal infections caused by Aspergillus fumigatus represent a great challenge for immuno-compromised patients. Pathogen detection is mediated by different receptors, including Toll-like receptors (TLRs), C-type lectins, and pentraxines," scientists in Wurzburg, Germany report. "However, little is known about their relevance for immature human dendritic cells (iDCs). The gene expression pattern of iDCs after exposure to A. fumigatus germ tubes was studied by use of whole genome microarray analysis and real-time polymerase chain reaction. Fungal receptors were targeted by means of short interfering RNAs (siRNAs), which were used to knock down expression of TLR2,...
Source: TB & Outbreaks Week (2008-04-29)
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