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Meningitis
Reports from R.A. Hirst and colleagues advance knowledge in meningitis
April 29th, 2008
According to recent research from Leicester, the United Kingdom, "The role played by pneumolysin and autolysin in pneumococcal meningitis is poorly understood. A rat model was used to investigate the disease, in which surgical implantation of a cisternal catheter allowed bacterial instillation and cerebrospinal fluid (CSF) sampling." "CSF infection of rats with wild-type pneumococci caused meningitis within 26 h, whereas isogenic mutants that do not express pneumolysin (Delta Ply) or autolysin (LytA(-)) caused very mild or no disease. Wild-type infections resulted in pneumococci in the CSF and cortical homogenates, but a minority of the rats infected with Delta Ply or...
Source: TB & Outbreaks Week (2008-04-29)
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