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Tuberculosis
Reports outline tuberculosis study results from Chungnam National University, Medical Department
May 6th, 2008
"Activated microglia elicits a robust amount of pro-inflammatory cytokines, which are implicated in the pathogenesis of tuberculosis in the central nervous system (CNS). However, little is known about the intracellular signaling mechanisms governing these inflammatory responses in microglia in response to Mycobacterium tuberculosis (Mtb)," scientists in South Korea report. "Murine microglial BV-2 cells and primary mixed glial cells were stimulated with sonicated Mtb (s-Mtb). Intracellular ROS levels were measured by staining with oxidative fluorescent dyes [2', 7'-Dichlorodihydrofluorescein diacetate (H(2)DCFDA) and dihydroethidium (DHE)]. NADPH oxidase activities were...
Source: TB & Outbreaks Week (2008-05-06)
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