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TB & Outbreaks Week

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Tuberculosis



Study results from Federal University in the area of tuberculosis published



May 6th, 2008

"Costimulatory and antigen-presenting molecules are essential to the initiation of T cell immunity to mycobacteria. The present study analyzed by immunocytochemistry, using monoclonal antibodies and alkaline phosphatase-anti-alkaline phosphatase method, the frequency of costimulatory (CD86, CD40, CD40L, CD28, and CD152) and antigen-presenting (MHC class II and CD1) molecules expression on human lung cells recovered by sputum induction from tuberculosis ( TB) patients (N = 22) and non-TB controls (N = 17)," scientists in Brazil report.

"TB cases showed a statistically significant lower percentage of HLA-DR+ cells than control subjects (21.9 +/- 4.2 vs 50.0 +/- 7.2%,...


Source: TB & Outbreaks Week (2008-05-06)

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