TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Life Sciences
Data on life sciences reported by researchers at University of Alabama
May 13th, 2008
"Ectromelia virus (ECTV) encodes an IFN-gamma-bincling protein (IFN-gamma BPECTV) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gamma BPECTV is an important virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox," scientists in the United States report. "The 2.2-angstrom crystal structure of the IFN-gamma BPECTV/IFN-gamma complex reveals IFN-gamma BPECTV consists of an lFN-gamma R1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization...
Source: TB & Outbreaks Week (2008-05-13)
|
