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Tuberculosis
Reports on tuberculosis findings from University of Alberta provide new insights
May 13th, 2008
According to recent research published in the Journal of Molecular Biology, "Mycobacterium tuberculosis ornithine carbamoyltransferase (Mtb OTC) catalyzes the sixth step in arginine biosynthesis; it produces citrulline from carbamoyl phosphate (CP) and ornithine (ORN). Here, we report the crystal structures of Mtb OTC in orthorhombic (form I) and hexagonal (form II) space groups." "The molecules in form II are complexed with CP and L-norvaline (NVA); the latter is a competitive inhibitor of OTC. The asymmetric unit in form I contains a pseudo hexamer with 32 point group symmetry. The CP and NVA in form II induce a remarkable conformational change in the 80s and...
Source: TB & Outbreaks Week (2008-05-13)
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