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Emphysema
New emphysema findings from University of British Columbia described
May 13th, 2008
According to recent research from Vancouver, Canada, "This review covers protease-antiprotease imbalance in the development of emphysema in smokers. This imbalance is likely to play a major pathogenic role in the development of emphysema in subjects with severe alpha(1)-antitrypsin deficiency who smoke because of a deficient antiprotease protection against neutrophil elastase release in the lung." "Neutrophil elastase is a potent elastolytic enzyme, and its instillation in the lungs of animals results in emphysema. Smoking attracts neutrophils to the lungs and there is an additional accumulation of neutrophils, because the abnormal antitrypsin polymerizes in the lungs...
Source: TB & Outbreaks Week (2008-05-13)
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