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Diarrhea
Study findings on diarrhea are outlined in reports from E. Kokkotou and colleagues
May 20th, 2008
"Clostridium difficile-associated colitis is an increasing cause of morbidity and mortality in hospitalized patients, with high relapse rates following conventional therapy. We sought to determine the efficacy of rifaximin, a novel nonabsorbed antibiotic, in the hamster model of C difficile-associated diarrhea (CDAD)," scientists in the United States report. "Hamsters received clindamycin subcutaneously and 24 h later were infected by gavage with one of two C. difficile strains: a reference strain (VPI 10463) and a current epidemic strain (BI17). Vancomycin (50 mg/kg of body weight) or rifaximin (100, 50, and 25 mg/kg) were then administered orally for 5 days beginning...
Source: TB & Outbreaks Week (2008-05-20)
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