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TB & Outbreaks Week

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Enzyme Research



Researchers' work from University of Melbourne focuses on enzyme research



May 20th, 2008

According to recent research from Melbourne, Australia, "Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target."

"The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined," wrote V. Mitsakos and colleagues, University of Melbourne.

The researchers concluded: "The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is...


Source: TB & Outbreaks Week (2008-05-20)

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