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Influenza
New influenza research from A. Srinivasan and colleagues discussed
May 20th, 2008
"The human adaptation of influenza A viruses is critically governed by the binding specificity of the viral surface hemagglutinin (HA) to long (chain length) alpha 2-6 sialylated glycan (alpha 2-6) receptors on the human upper respiratory tissues. A recent study demonstrated that whereas the 1918 H1N1 pandemic virus, A/South Carolina/1/1918 (SC18), with alpha 2-6 binding preference transmitted efficiently, a single amino acid mutation on HIA resulted in a mixed alpha 2-3 sialylated glycan (alpha 2-3)/alpha 2-6 binding virus (NY18) that transmitted inefficiently," investigators in the United States report. "To define the biochemical basis for the observed differences in...
Source: TB & Outbreaks Week (2008-05-20)
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