TB & Outbreaks Week
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Tuberculosis
New tuberculosis findings from Harvard University, Medical Department published
May 20th, 2008
According to recent research from the United States, "Nearly 1.7 billion people are infected with Mycobacterium tuberculosis. Its ability to survive intracellularly is thought to be central to its success as a pathogen, but how it does this is poorly understood." "Using a Drosophila model of infection, we identify three host cell activities, Rab7, CG8743, and the ESCRT machinery, that modulate the mycobacterial phagosome. In the absence of these factors the cell no longer restricts growth of the non-pathogen Mycobacterium smegmatis. Hence, we identify factors that represent unique vulnerabilities of the host cell, because manipulation of any one of them alone is...
Source: TB & Outbreaks Week (2008-05-20)
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