TB & Outbreaks Week
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Enzyme Research
Reports on enzyme research findings from Purdue University provide new insights
May 27th, 2008
According to recent research from the United States, "The penultimate step in the biosynthesis of riboflavin is catalyzed by lumazine synthase." "Three metabolically stable analogues of the hypothetical intermediate proposed to arise after phosphate elimination in the lumazine synthase-catalyzed reaction were synthesized and evaluated as lumazine synthase inhibitors. All three intermediate analogues were inhibitors of Mycobacterium tuberculosis lumazine synthase, Bacillus subtilis lumazine synthase, and Schizosaccharomyces pombe lumazine synthase, while one of them proved to be an extremely potent inhibitor of Escherichia coli riboflavin synthase with a K-i of 1.3 nM,"...
Source: TB & Outbreaks Week (2008-05-27)
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