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Enzyme Research
Study results from University of California, Medical Department provide new insights into enzyme research
May 27th, 2008
"Tissue availability of the active vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] is dependent on expression of the activating enzyme la-hydroxylase (CYT27b1) and its catabolic counterpart 24-hydroxylase (CYP24). The activity of these two enzymes is in turn controlled by factors including affinity of the serum vitamin D-binding protein (DBP) for 25-hydroxyvitamin D [25(OH)D]; the availability of enzyme cofactors; and the relative amount of hydroxylase gene product expressed," scientists writing in the Journal of Bone and Mineral Research report. "In recent years, it has become clear that directed trafficking of substrate and enzyme is also a pivotal...
Source: TB & Outbreaks Week (2008-05-27)
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