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Influenza
Research from Northwestern University broadens understanding of influenza
May 27th, 2008
"The virulence of influenza virus is a multigenic trait. One determinant of virulence is the multifunctional NS1 protein that functions in several ways to defeat the cellular innate immune response," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Recent large-scale genome sequence analysis of avian influenza virus isolates indicated that four C-terminal residues of the NS1 protein is a PDZ ligand domain of the X-S/T-X-V type and it was speculated that it may represent a virulence determinant. To test this hypothesis, by using mice as a model system, the four C-terminal amino acid residues...
Source: TB & Outbreaks Week (2008-05-27)
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