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Meningitis
Researchers' work from University of Dublin, Trinity College focuses on meningitis
May 27th, 2008
According to recent research from Dublin, Ireland, "Escherichia coli is the principal gram-negative causative agent of sepsis and meningitis in neonates. The pathogenesis of meningitis due to E. coli K1 involves mucosal colonization, transcytosis of epithelial cells, survival in the bloodstream, and eventually invasion of the meninges." "The last two aspects have been well characterized at a molecular level. Less is known about the early stages of pathogenesis, i.e., adhesion to and invasion of epithelial cells. We have previously reported that the Hek protein causes autoaggregation and can mediate adherence to and invasion of epithelial cells. Here, we report that...
Source: TB & Outbreaks Week (2008-05-27)
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