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Enzyme Research
Investigators at University of Groningen zero in on enzyme research
June 3rd, 2008
According to a study from Netherlands, "The Rhodococcus erythropolis SQ1 kstD3 gene was cloned, heterologously expressed and biochemically characterized as a KSTD3 (3-keto-5 alpha-steroid Delta'-dehydrogenase). Upstream of kstD3, an ORF (open reading frame) with similarity to Delta(4) KSTD (3-keto-5 alpha-steroid Delta(4)-dehydrogenase) was found, tentatively designated kst4D." "Biochemical analysis revealed that the Delta(1) KSTD3 has a clear preference for 3-ketosteroids with a saturated A-ring, displaying highest activity on 5 alpha-AD (5 alpha-androstane-3,17-dione) and 5 alpha-T (5 alpha-testosterone; also known as 17 beta-hydroxy-5 alpha-androstane-3-one). The...
Source: TB & Outbreaks Week (2008-06-03)
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