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TB & Outbreaks Week

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Enzyme Research



Research from University of Gottingen in the area of enzyme research published



June 3rd, 2008

According to a study from Germany, "Aspergillosis is a disease determined by various factors that influence fungal growth and fitness. A conserved signal transduction cascade linking environmental stress to amino acid homeostasis is the Cross-Pathway Control (CPC) system that acts via phosphorylation of the translation initiation factor eIF2 by a sensor kinase to elevate expression of a transcription factor."

"Ingestion of Aspergillus fumigatus conidia by macrophages does not trigger this stress response, suggesting that their phagosomal microenvironment is not deficient in amino acids. The cpcC gene encodes the CPC eIF2 alpha kinase, and deletion mutants show increased...


Source: TB & Outbreaks Week (2008-06-03)

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