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Infectious Disease
New data from E. Frigimelica et al illuminate research in infectious disease
June 3rd, 2008
According to recent research published in the Journal of Infectious Diseases, "Cathelicidins play a pivotal role in innate immunity, providing a first barrier against bacterial infections at both mucosal and systemic sites. In this work, we have investigated the mechanisms by which Neisseria meningitidis serogroup B (MenB) survives at the physiological concentrations of human and mouse cathelicidin LL37 and CRAMP, respectively." "By analyzing the global transcription profile of MenB in the presence or absence of CRAMP, 21 genes were found to be differentially expressed. Among these genes, the hypothetical genes NMB0741 and NMB1828 wereup-regulated. When either of...
Source: TB & Outbreaks Week (2008-06-03)
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