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TB & Outbreaks Week

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Legionnaire Disease



Investigators at University of British Columbia zero in on legionnaire disease



June 3rd, 2008

"Legionaminic acid is a nine-carbon (x-keto acid that is similar in structure to other members of the sialic acid family that includes neuraminic acid and pseudaminic acid. It is found as a component of the lipopolysaccharide in several bacterial species and is perhaps best known for its presence in the O-antigen of the causative agent of Legionnaires' disease, Legionella pneumophila," scientists in Vancouver, Canada report.

"In this work, the enzymes responsible for the biosynthesis and activation of N,N'-diacetyllegionaminic acid are identified for the first time. A cluster of three L. pneumophila genes bearing homology to known sialic acid biosynthetic genes...


Source: TB & Outbreaks Week (2008-06-03)

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