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Tuberculosis
Study data from University of Washington provide new insights into tuberculosis
June 3rd, 2008
"A novel FAD-dependent thymidylate synthase, ThyX, is present in a variety of eubacteria and archaea, including the mycobacteria. A short motif found in all thyX genes, RHRX7-8S, has been identified," investigators in the United States report. "The three-dimensional structure of the Mycobacterium tuberculosis ThyX enzyme has been solved. Building upon this information, we used directed mutagenesis to produce 67 mutants of the M. tuberculosis thyX gene. Each enzyme was assayed to determine its ability to complement the defect in thymidine biosynthesis in a Delta thyA strain of Escherichia coli. Enzymes from selected strains were then tested in vitro for their ability to...
Source: TB & Outbreaks Week (2008-06-03)
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