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Tuberculosis
New research on tuberculosis from R.G. Silva and co-authors summarized
June 10th, 2008
"beta-Ketoacyl-ACP reductase catalyzes the NADPH-dependent reduction of P-ketoacyl-acyl carrier protein to generate beta-hydroxyacylacyl carrier protein and NADP(+), the second step of the fatty acid elongation system type II of bacteria, plants, and apicomplexan organisms. Here, a modified and more efficient purification protocol is reported for recombinant Mycobacterium tuberculosis beta-ketoacyl-ACP reductase (MabA)," researchers in Porto Alegre, Brazil report. "The increase in alpha-secondary deuterium kinetic isotope effect values measured at pH 10 as compared to those obtained at pH 7 points to isotope- and pH-sensitive steps occurring concomitantly. Equilibrium...
Source: TB & Outbreaks Week (2008-06-10)
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