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Legionnaire Disease Cell Biology
Research conducted at Charite University has provided new information about legionnaire disease cell biology
June 10th, 2008
Current study results from the report, 'NAIP and Ipaf control Legionella pneumophila replication in human cells,' have been published. According to recent research from Berlin, Germany, "In mice, different alleles of the mNAIP5 (murine neuronal apoptosis inhibitory protein-5)/mBirc1e gene determine whether macrophages restrict or support intracellular replication of Legionella pneumophila, and whether a mouse is resistant or (moderately) susceptible to Legionella infection. In the resistant mice strains, the nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) family member mNAIP5/mBirc1e, as well as the NLR protein mIpaf (murine ICE protease-activating factor), are...
Source: TB & Outbreaks Week (2008-06-10)
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