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Life Sciences
Researchers from Institute of Pharmaceutical Science describe findings in life sciences
June 10th, 2008
New investigation results, 'Antimycobacterial activity of diphenylpyraline derivatives,' are detailed in a study published in European Journal of Medicinal Chemistry. "2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy," researchers in Graz, Austria report. "Their activity against Mycobacterium tuberculosis H(37)Rv as well as their cytotoxicity against human cells (HEK-293) have been determined via in vitro assays. The antimycobacterial potency was in general increased by...
Source: TB & Outbreaks Week (2008-06-10)
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