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Monoclonal Antibodies
Researchers from University of North Carolina report recent findings in monoclonal antibodies
June 17th, 2008
"Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002, and detailed phylogenetic and epidemiological analyses have suggested that it originated from animals. The spike (S) glycoprotein has been identified as a major component of protective immunity, and 23 different amino acid changes were noted during the expanding epidemic," researchers in the United States report. "Using a panel of SARS-CoV recombinants bearing the S glycoproteins from isolates representing the zoonotic and human early, middle, and late phases of the epidemic, we identified 23 monoclonal antibodies (NIAbs) with neutralizing activity against one or multiple SARS-CoV spike variants...
Source: TB & Outbreaks Week (2008-06-17)
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