TB & Outbreaks Week
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Tuberculosis
Research on tuberculosis detailed by R. Bryk and co-authors
June 17th, 2008
According to recent research from the United States, "Antibiotics are typically more effective against replicating rather than nonreplicating bacteria. However, a major need in global health is to eradicate persistent or nonreplicating subpopulations of bacteria such as Mycobacterium tuberculosis (Mtb)." "Hence, identifying chemical inhibitors that selectively kill bacteria that are not replicating is of practical importance. To address this, we screened for inhibitors of dihydrolipoamide acyltransferase (DlaT), an enzyme required by Mtb to cause tuberculosis in guinea pigs and used by the bacterium to resist nitric oxide-derived reactive nitrogen intermediates, a...
Source: TB & Outbreaks Week (2008-06-17)
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