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Cloning
Research on cloning reported by D.B. Castropinto et al
June 24th, 2008
According to recent research from Brazil, "Trypanothione disulfide (T[S](2)), an unusual form of glutathione found in parasitic protozoa, plays a crucial role in the regulation of the intracellular thiol redox balance and in the defense against oxidative stress. Trypanothione reductase (TR) is central to the thiol metabolism in all trypanosomatids, including the human pathogens Trypanosoma cruzi, Trypanosoma brucei and Leishmania." "Here we report the cloning, sequencing and expression of the TR encoding gene from L. (L.) amazonensis. Multiple protein sequence alignment of all known trypanosomatid TRs highlights the high degree of conservation and illustrates the...
Source: TB & Outbreaks Week (2008-06-24)
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