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HIV/AIDS
Findings from University of Witwatersrand, Medical Department broaden understanding of HIV/AIDS
June 24th, 2008
"This study investigated the genotype and phenotype of HIV-1 isolates of 20 South African AIDS patients," scientists in Johannesburg, South Africa report. "We found the highest percentage of CXCR4 usage among primary isolates, in which 30% efficiently utilized CXCR4 and exhibited the syncytium-inducing phenotype. Phylogenetic analysis of env confirmed that 19 of the 20 were subtype C, and syncytium-inducing viruses had genetic changes in the V3 loop, characteristic of CXCR4 usage," wrote B.J. Connell and colleagues, University of Witwatersrand, Medical Department. The researchers concluded: "Results imply that the frequency of CXCR4-utilizing subtype...
Source: TB & Outbreaks Week (2008-06-24)
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