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Tuberculosis
New tuberculosis findings from Sri Bhagawan Mahaveer Jain College described
June 24th, 2008
According to recent research from Bangalore, India, "The present paper reports a bio-computational study carried out with the aim of understanding the binding mode of anti-TB herbal ligands onto the homology modeled structure of fatty acid synthase of Mycobacterium tuberculosis (M.tb) H37Rv. Sequence alignment of beta-ketoacyl ACP synthase (KAS) domain of the protein with other related KAS sequences of PDB database revealed high degree of sequence variation." "However, the catalytic triad comprising of CHH (cys(150)-his(279)-his(320)) was found to be conserved in the KAS sequence of M.tb H37Rv. The tertiary structure of this protein predicted using genetic algorithm...
Source: TB & Outbreaks Week (2008-06-24)
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