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HIV/AIDS
Reports from University of Marburg add new data to research in HIV/AIDS
July 1st, 2008
According to recent research from Marburg, Germany, "Infections with the human immunodeficiency virus, which inevitably lead to the development of AIDS, are still among the most serious global health problems causing more than 2.5 million deaths per year. In the pathophysiological processes of this pandemic, HIV protease has proven to be an invaluable drug target because of its essential role in the virus' replication process." "By use of pyrrolidine as core structure, symmetric 3,4-bis-N-alkylsulfonamides were designed and synthesized enantioselectively from D-(-)-tartaric acid as a new class of HIV protease inhibitors. Structure-guided design using the cocrystal...
Source: TB & Outbreaks Week (2008-07-01)
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