TB & Outbreaks Week
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Life Sciences
Recent findings from University of Groningen highlight research in life sciences
July 1st, 2008
According to recent research published in the Biophysical Journal, "The tension-driven gating process of MscL from Mycobacterium tuberculosis, Tb-MscL, has been addressed at near-atomic detail using coarse-grained molecular dynamics simulations. To perform the simulations, a novel coarse-grained peptide model based on a thermodynamic parameterization of the amino-acid side chains has been applied." "Both the wild-type Tb-MscL and its gain-of-function mutant V21 D embedded in a solvated lipid bilayer have been studied. To mimic hypoosmotic shock conditions, simulations were performed at increasing levels of membrane tension approaching the rupture threshold of the...
Source: TB & Outbreaks Week (2008-07-01)
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