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Meningitis
Research on meningitis discussed by R.J. Bernardi and co-researchers
July 1st, 2008
According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " A phase I study of intrathecal (IT) gemcitabine was performed to define a safe dose and characterize the toxicity profile and CSF pharmacokinetics of gemcitabine and its major metabolite 2',2'-difluoro-deoxyuridine (dFdU) in patients 3 years of age and older with neoplastic meningitis. Experimental design Gemcitabine was administered via Ommaya reservoir or lumbar puncture at three dose levels: 5 mg weekly, 5 mg twice-weekly, and 10 mg twice-weekly using a standard phase I dose escalation design." "Serial CSF samples were obtained for pharmacokinetic studies in seven...
Source: TB & Outbreaks Week (2008-07-01)
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