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TB & Outbreaks Week

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Plague



Data from H. Gao et al provide new insights into plague



July 1st, 2008

"The ferric uptake regulator (Fur) is a predominant bacterial regulator controlling the iron assimilation functions in response to iron availability. Our previous microarray analysis on Yersinia pestis defined the iron-Fur modulon," scientists writing in the Journal of Bacteriology report.

"In the present work, we reannotated the iron assimilation genes in Y. pestis, and the resulting genes in complementation with those disclosed by microarray constituted a total of 34 genome loci (putative operons) that represent the potential iron-responsive targets of Fur. The subsequent real-time reverse transcription-PCR (RT-PCR) in conjunction with the primer extension...


Source: TB & Outbreaks Week (2008-07-01)

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