TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Tuberculosis
Findings from St. George's University provide new insights into tuberculosis
July 1st, 2008
"The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are essential for cell survival," scientists writing in the journal Infection and Immunity report. "A mutant lacking Cpn60.1 was indistinguishable from the wild-type organism in plate and broth culture and within marine macrophages, although it showed increased sensitivity to high temperature (55 degrees C). However, infection of mice with the Delta cpn60.1 mutant revealed a major difference from the wild-type organism. In spite of having equal numbers of bacteria in...
Source: TB & Outbreaks Week (2008-07-01)
|
