TB & Outbreaks Week
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Tuberculosis
Study data from C.D. Sohaskey and co-authors update knowledge of tuberculosis
July 1st, 2008
"When oxygen is slowly depleted from growing cultures of Mycobacterium tuberculosis, they enter a state of nonreplicating persistence that resembles the dormant state seen with latent tuberculosis. In this hypoxic state, nitrate reductase activity is strongly induced," researchers in the United States report. "Nitrate in the medium had no effect on long-term persistence during gradual oxygen depletion (Wayne model) for up to 46 days, but significantly enhanced survival during sudden anaerobiosis. This enhancement required a functional nitrate reductase. Thioridazine is a member of the class of phenothiazines that act, in part, by inhibiting respiration. Thioridazine was...
Source: TB & Outbreaks Week (2008-07-01)
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