Drug Resistance

Research from McMaster University reveals new findings on drug resistance

Published in TB and Outbreaks Week, July 1st, 2008

According to a study from Hamilton, Canada, "The rifamycin antibiotic rifampin is important for the treatment of tuberculosis and infections caused by multidrug-resistant Staphylococcus aureus. Recent iterations of the rifampin core structure have resulted in new drugs and drug candidates for the treatment of a much broader range of infectious diseases."

"This expanded use of rifamycin antibiotics has the potential to select for increased resistance. One poorly characterized mechanism of resistance is through Arr enzymes that catalyze ADP-ribosylation of rifamycins. We find that genes encoding predicted Arr enzymes are widely distributed in the genomes of pathogenic and...

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Source: TB and Outbreaks Week (2008-07-01)

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