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Drug Resistance
Research from R. Mukherjee and co-authors in the area of drug resistance published
July 8th, 2008
"Rapid emergence of multi-drug resistance in Mycobacterium tuberculosis has necessitated the development of newer candidate drugs which can selectively inhibit the growth of the organism. Among the best targets available today, transcription machinery is, by far, the most important one and the antibiotic rifampicin binds to a specific site on the enzyme RNA polymerase," researchers in Bangalore, India report. "However, it is not very effective towards the stationary phase of the organism or the persistors. In order to address this problem, we report here a protocol for generating an affinity tagged RNA polymerase, which can be purified easily from different phases of...
Source: TB & Outbreaks Week (2008-07-08)
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