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West Nile Virus
New west nile virus data have been reported by H.P. Dong and co-authors
July 15th, 2008
"Flaviviruses encode a single methyltransferase domain that sequentially catalyzes two methylations of the viral RNA cap, GpppA-RNA -> m(7) GpppA-RNA -> m(7) GpppAm-RNA, by using S-adenosyl-L-methionine (SAM) as a methyl donor. Crystal structures of flavivirus methyltransferases exhibit distinct binding sites for SAM, GTP, and RNA molecules," researchers in the United States report. "Biochemical analysis of West Nile virus methyltransferase shows that the single SAM-binding site donates methyl groups to both N7 and 2'-O positions of the viral RNA cap, the GTP-binding pocket functions only during the 2'-O methylation, and two distinct sets of amino acids in the...
Source: TB & Outbreaks Week (2008-07-15)
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