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Obesity and Diabetes

Orexigen(R) Initiates Second Phase IIb Empatic(TM) Trial on Schedule

Published in TB and Outbreaks Week, July 22nd, 2008

Orexigen(R) Therapeutics, Inc. (NASDAQ:OREX) announced that it has begun randomizing patients in ZB-202, a second Phase IIb clinical trial for Empatic(TM), one of the Company's two late-stage obesity product candidates. The trial is designed to build on highly encouraging safety and efficacy results from a previous Phase IIb trial of Empatic, which demonstrated robust weight loss at 48 weeks ranging from approximately 11 percent to 15 percent in obese patients completing the trial and a discontinuation rate due to adverse events that was not significantly different than placebo.

"Initiation of ZB-202 is an important milestone for our Empatic program and the final...

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