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TB & Outbreaks Week

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Central Nervous System Infection



Studies from Iwate Medical University, Medical Department further understanding of central nervous system infection



July 22nd, 2008

"Shiga toxins (Stxs) are the major agents responsible for hemorrhagic colitis and hemolyticuremic syndrome (HUS) during infections caused by Stx-producing Escherichia coli (STEC) such as serotype O157:H7. Central nervous system (CNS) involvement is an important determinant of mortality in diarrhea associated-HUS," scientists writing in the Journal of Neuroinflammation report.

"It has been suggested that vascular endothelial injuries caused by Stxs play a crucial role in the development of the disease. The current study investigates the relationship between the cytotoxic effects of Stxs and inflammatory responses in a rabbit brain treated with Stx2. In a rabbit...


Source: TB & Outbreaks Week (2008-07-22)

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