TB & Outbreaks Week
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Life Sciences
Reports from University of Notre Dame describe recent advances in life sciences
July 22nd, 2008
According to recent research from the United States, "The salient feature of dendritic cells (DC) is the initiation of appropriate adaptive immune responses by discriminating between pathogens. Using a prototypic model of intracellular infection, we previously showed that Leishmania major parasites prime human DC for efficient interleukin-12 (IL-12) secretion. L. major infection is associated with self-limiting cutaneous disease and powerful immunity." "In stark contrast, the causative agent of visceral leishmaniasis, Leishmania donovani, does not prime human DC for IL-12 production. Here, we report that DC priming by L. major infection results in the early activation...
Source: TB & Outbreaks Week (2008-07-22)
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