TB & Outbreaks Week
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Life Sciences
Research conducted at University of New Mexico has provided new information about life sciences
July 22nd, 2008
According to recent research published in the Embo Journal, "Autophagy is a newly recognized innate defense mechanism, acting as a cell-autonomous system for elimination of intracellular pathogens. The signals and signalling pathways inducing autophagy in response to pathogen invasion are presently not known." "Here we show that autophagy is controlled by recognizing conserved pathogen-associated molecular patterns (PAMPs). We screened a PAMP library for effects on autophagy in RAW 264.7 macrophages and found that several prototype Toll-like receptor (TLR) ligands induced autophagy. Single-stranded RNA and TLR7 generated the most potent effects. Induction of...
Source: TB & Outbreaks Week (2008-07-22)
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