TB & Outbreaks Week
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Life Sciences
Studies conducted at University of Illinois, Medical Department on life sciences recently published
July 22nd, 2008
"Yersinia pestis is the etiologic agent of bubonic and pneumonic plagues. It is speculated that K pestis hijacks antigen-presenting cells (APCs), such as dendritic cells (DCs) and alveolar macrophages, in order to be delivered to lymph nodes," scientists in the United States report. "However, how APCs initially capture the bacterium remains uncharacterized. It is well known that HIV-1 uses human DC-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIGN) (CD209) receptor, expressed by APCs, to be captured and delivered to target cell, such as CD4+ lymphocytes. Several gram-negative bacteria utilize their core lipopolysaccharides (LPS) as ligands to...
Source: TB & Outbreaks Week (2008-07-22)
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