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Tuberculosis
New tuberculosis findings from University of Zurich described
July 22nd, 2008
According to recent research published in the journal Cell Host & Microbe, "Mycobacterium tuberculosis (Mtb) parasitizes host macrophages and subverts host innate and adaptive immunity. Several cytokines elicited by Mtb are mediators of mycobacterial clearance or are involved in tuberculosis pathology." "Surprisingly, interleukin-1 beta (IL-1 beta), a major proinflammatory cytokine, has not been implicated in host-Mtb interactions. IL-1 beta is activated by processing upon assembly of the inflammasome, a specialized inflammatory caspase-activating protein complex. Here, we show that Mtb prevents inflammasome activation and IL-1 beta processing. An Mtb gene, zmp1,...
Source: TB & Outbreaks Week (2008-07-22)
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