TB & Outbreaks Week
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Tuberculosis
New tuberculosis study findings recently were reported by D.M. Hunt and co-researchers
July 22nd, 2008
"Single nucleotide polymorphisms (SNPs) are present in the global transcriptional regulator cyclic AMP (cAMP) receptor protein (CRP) of the attenuated vaccine strain Mycobacterium bovis, bacillus Calmette-Guerin (BCG). We have found that these SNPs resulted in small but, significant changes in the expression of a number of genes in M. tuberculosis when a deletion of the Rv3676 CRP was complemented by the BCG allele, compared to complementation by the M. tuberculosis allele," scientists in Mill Hill, the United Kingdom report. "We can explain these changes in gene expression by modeling the structure of the mycobacterial protein on the known structure of CRP from...
Source: TB & Outbreaks Week (2008-07-22)
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