TB & Outbreaks Week
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Vaccines
Report summarizes vaccines study findings from L.E. Quenee and co-researchers
July 22nd, 2008
According to recent research from the United States, "Yersinia pestis, the highly virulent agent of plague, is a biological weapon." "Strategies that prevent plague have been sought for centuries, and immunization with live, attenuated (nonpigmented) strains or subunit vaccines with F1 (Caf1) antigen is considered effective. We show here that immunization with live, attenuated strains generates plague-protective immunity and Immoral immune responses against F1 pilus antigen and LcrV. Y. pestis variants lacking caf1 (F1 pili) are not only fully virulent in animal models of bubonic and pneumonic plague but also break through immune responses generated with live,...
Source: TB & Outbreaks Week (2008-07-22)
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