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Influenza
Reports outline influenza study findings from University of Marburg
July 29th, 2008
According to recent research published in the journal Plos Pathogens, "We have previously reported that mutations in the polymerase proteins PB1, PB2, PA, and the nucleocapsid protein NP resulting in enhanced transcription and replication activities in mammalian cells are responsible for the conversion of the avian influenza virus SC35 ( H7N7) into the mouse-adapted variant SC35M. We show now that adaptive mutations D701N in PB2 and N319K in NP enhance binding of these proteins to importin alpha 1 in mammalian cells." "Enhanced binding was paralleled by transient nuclear accumulation and cytoplasmic depletion of importin alpha 1 as well as increased transport of...
Source: TB & Outbreaks Week (2008-07-29)
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