TB & Outbreaks Week
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Life Sciences
Data on life sciences discussed by M. Fang and colleagues
July 29th, 2008
"Ectromelia virus ( ECTV) is an orthopoxvirus ( OPV) that causes mousepox, the murine equivalent of human smallpox. C57BL/6 (B6) mice are naturally resistant to mousepox due to the concerted action of innate and adaptive immune responses," researchers in the United States report. "Previous studies have shown that natural killer (NK) cells are a component of innate immunity that is essential for the B6 mice resistance to mousepox. However, the mechanism of NK cell-mediated resistance to OPV disease remains undefined. Here we show that B6 mice resistance to mousepox requires the direct cytolytic function of NK cells, as well as their ability to boost the T cell response....
Source: TB & Outbreaks Week (2008-07-29)
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