TB & Outbreaks Week
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Life Sciences
Research conducted at Medical University of South Carolina has provided new information about life sciences
July 29th, 2008
According to recent research from the United States, "Cryptococcus neoformans (Cn) is the most common cause of fungal meningitis worldwide. In infected patients, growth of the fungus can occur within the phagolysosome of phagocytic cells, especially in non-activated macrophages of immunocompromised subjects." "Since this environment is characteristically acidic, Cn must adapt to low pH to survive and efficiently cause disease. In the present work, we designed, tested, and experimentally validated a theoretical model of the sphingolipid biochemical pathway in Cn under acidic conditions. Simulations of metabolic fluxes and enzyme deletions or downregulation led to...
Source: TB & Outbreaks Week (2008-07-29)
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